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> Journal Covers

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Selected Journal Covers

Killian et al, Hum. Mol. Genet. 10: 1721-1728, 2001. [PDF]

Waterland and Jirtle, Mol. Cell. Biol. 23: 5293-5300, 2003. [PDF]

Weidman et al, Genome Res. 17: 1723-1730, 2007. [PDF]

Video Presentations

> Distinguished Achievement Award Video

Honors and Other Professional Activities

Undergraduate Honors, Sigma Xi, Tau Beta Pi

1. U.S. Atomic Energy Commission Licensed Nuclear Reactor Operator, UW - Madison, WI, 1968 - 1970.

2. Szulman Lecture, ÒImprinting Evolution: Silence and the Lambs,Ó University of Pittsburgh, Pittsburgh, PA, 2002.

3. NCI Metabolic Pathology Study Section, Member, Bethesda, MD, 1993 - 1996.

4. NCI Distinguished Seminar Lecture, "Evolution of Imprinted Cancer Susceptibility Genes,", NCI-Fredrick, Fredrick, MD, 2003.

5. Nobel Symposium on Epigenetic Reprogramming in Development and Disease, ÒBiological Consequences of the Divergent Evolution of M6P/IGF2R ImprintingÓ, Stockholm, Sweden, 2004.

6. Fetterman Endowed Lecture, ÒEpigenetic Basis of Human Health and Disease,Ó University of Pittsburgh, Pittsburgh, PA, 2006.

7. 20th Annual Roland D. Pinkham Basic Science Lectureship, Epigenetics: One Step above the Genome, ÒEnvironmental/Dietary Influences on Gene Imprinting and Consequences for Enhanced Disease Susceptibility,Ó Seattle, WA, 2006.

8. Distinguished Achievement Award, College of Engineering, University of Wisconsin, Madison, WI, 2006.

9. Robert T. Simpson Endowed Lecture in Molecular Medicine, Department of Biochemistry and Molecular Biology, ÒEpigenetics in Human Health and Disease,Ó Pennsylvania State University, University Park, PA, 2007.

10. Featured Scientist on NOVA and ScienceNow Epigenetics Television Programs and The DNA Files program - Rewriting Heredity: Environment and the Genome and The People's Pharmacy NPR program - Sex Hormone Disruption.

11. Time Magazine Person of the Year Nominee, 2007.

12. NIH Epigenomics Roadmap Initiative Workshop Member, 2007.

13. Esther B. O'Keeffe Charitable Foundation Award, 2007.

14. Epigenetic Medicine Award Recipient, 2008.

15. Renaissance Weekend, Invited Participant, 2008.

Select Publications (Since 1995)

1. De Souza A.T., Hankins, G.R., Washington, M.K., Orton, T.C., and Jirtle RL. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat. Genet. 11: 447-449, 1995. [PDF]

2. Yamada, T., De Souza, A.T., Finkelstein, S., and Jirtle RL. Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis. Proc. Natl. Acad. Sci. USA 94: 10351-10355, 1997. [PDF]

3. Killian, J.K., Byrd, J.C, Jirtle, J.V., Munday, B.L., Stoskopf, M.K., and Jirtle RL. M6P/IGF2R imprinting evolution in mammals. Mol. Cell 5: 707-716, 2000. [Press Release] [PDF]

4. Wylie, A.A., Murphy, S.K., Orton, T.C., and Jirtle RL. Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation. Genome Res. 10: 1711-1718, 2000. [PDF]

5. Killian, J.K., Buckley, T.R., Stewart, N., Barry L. Munday, B.L., and Jirtle RL. Marsupials and eutherians reunited: genetic evidence for the theria hypothesis of mammalian evolution. Mamm. Genome 12: 513-517, 2001. [Press Release] [Journal Cover] [PDF]

6. Killian, J.K., Nolan C.M., Wylie A.A., Li T., Vu T.H., Hoffman A.R., and Jirtle RL. Divergent evolution in M6P/IGF2R imprinting from the Jurassic to the Quaternary. Hum. Mol. Genet. 10: 1721-1728, 2001. [Press Release] [Journal Cover] [PDF]

7. Freking, B.A., Murphy, S.K., Wylie, A.A., Rhodes, S.J., Keele, J.W., Leymaster, K.A., Jirtle RL, and Smith, T.P. Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals. Genome Res. 12: 1496-1506, 2002. [Press Release] [Journal Cover] [PDF]

8. Wylie, A.A., Pulford, D.J., McVie-Wylie, A.J., Waterland, R.A., Evans, H.K., Chen, Y.T., Nolan, C.M., Orton, T.C., and Jirtle RL. Tissue-specific inactivation of murine M6P/IGF2R. Am. J. Pathol. 162: 321-328, 2003. [PDF]

9. Waterland, R.A. and Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol. Cell Biol. 23: 5293-5300, 2003. [Press Release] [Journal Cover] [PDF]

10. Weidman, J.R., Murphy, S.K., Nolan, C.M., Dietrich, F.S., and Jirtle RL. Phylogenetic footprint analysis of IGF2 in extant mammals. Genome Res. 14: 1726-1732, 2004. [Journal Cover] [PDF]

11. Luedi, P.P., Hartemink, A.J., and Jirtle RL. Genome-wide prediction of imprinted murine genes. Genome Res. 15: 875-884, 2005. [PDF]

12. Evans, H.K, Weidman, J.R,. Cowley, D.O., and Jirtle RL. Comparative phylogenetic analysis of Blcap/Nnat reveals eutherian-specific imprinted gene. Mol. Biol. Evol. 22: 1740-1748, 2005. [PDF]

13. Dolinoy, D.C., Weidman, J.R., Waterland, R.A., and Jirtle RL. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ. Health Perspect. 14: 567-572, 2006. [Press Release] [PDF]

14. Jirtle RL., and Weidman, J.R. Imprinted and more equal. Am. Sci. 95: 143-149, 2007. [PDF]

15. Jirtle, R.L., and Skinner, M.K. Environmental epigenomics and disease susceptibility. Nat. Rev. Genet. 8: 253-562, 2007. [PDF]

16. Mikkelsen, T.S., Wakefield, M.J., Aken, B., Amemiya, C.T., Chang, J.L., Duke, S., Garber, M., Gentles, A.J., Goodstadt, L., Heger, A., Jurka, J., Kamal, M., Mauceli, E., Searle, S.M., Sharpe, T., Baker, M.L., Batzer, M.A., Benos, P.V., Belov, K., Clamp, M., Cook, A., Cuff, J., Das, R., Davidow, L., Deakin, J.E., Fazzari, M.J., Glass, J.L., Grabherr, M., Greally, J.M., Gu, W., Hore, T.A., Huttley, G.A., Kleber, M., Jirtle RL, Koina, E., Lee, J.T., Mahony, S., Marra, M.A., Miller, R.D., Nicholls, R.D., Oda, M., Papenfuss, A.T., Parra, Z.E., Pollock, D.D., Ray, D.A., Schein, J.E., Speed, T.P., Thompson, K., VandeBerg, J.L., Wade, C.M., Walker, J.A., Waters, P.D., Webber, C., Weidman, J.R., Xie, X., Zody, M.C.; Broad Institute Genome Sequencing Platform; Broad Institute Whole Genome Assembly Team, Graves, J.A., Ponting, C.P., Breen, M., Samollow, P.B., Lander, E.S., and Lindblad-Toh, K. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature 447: 167-177, 2007. [PDF]

17. Dolinoy DC, Huang, D., and Jirtle RL. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc. Natl. Acad. Sci. USA 104: 13056-13061, 2007. [Press Release] [PDF]

18. Luedi, P.P., Dietrich, F.S., Weidman, J.R., Bosko, J.M., Jirtle RL, and Hartemink, A.J. Computational and experimental identification of novel human imprinted genes. Genome Res. 17: 1723-1730, 2007. [Press Release] [Cover] [PDF]