Patents
M6P/IGF-II Receptor Tumor Suppressor Gene
Patent Number: 5,874,222
Date of Patent: Feb. 23, 1999
- The present invention relates, in general, to a suppressor and, in particular, to the mannose 6-phosphate/insulin-like growth factor-II (M6P/IGF-II) receptor and to diagnostic and therapeutic approaches based on same.
Cancer Prognosis with the M6P/IGF-II Gene
Patent Number: 6,218,127
Date of Patent: April 17, 2001
- The present invention relates, in general, to cancer prognosis and, in particular, to a method of assessing the prognosis of a patient using the M6P/IGF2-II receptor.
Imprinted Genes and Disease
Provisional Patent:
Date of Provisional Patent: December 23, 2002
- The presently disclosed subject matter relates to the field of imprinted genes. More particularly, the presently disclosed subject matter relates to 10 methods and compositions for identifying imprinted genes, for genotyping subjects with respect to one or more imprinted genes, and for diagnosing and/or determining a susceptibility of a subject to a disease process associated with expression or lack of expression of an imprinted gene.
Honors and Endowed Lectureships
1. Szulman Lecture, ÒImprinting Evolution: Silence and the Lambs,Ó University of Pittsburgh, Pittsburgh, PA, 2002.
2. NCI Distinguished Seminar Lecture, "Evolution of Imprinted Cancer Susceptibility Genes,", NCI-Fredrick, Fredrick, MD, 2003.
3. Nobel Symposium on Epigenetic Reprogramming in Development and Disease, ÒBiological Consequences of the Divergent Evolution of M6P/IGF2R ImprintingÓ, Stockholm, Sweden, 2004.
4. Fetterman Endowed Lecture, ÒEpigenetic Basis of Human Health and Disease,Ó University of Pittsburgh, Pittsburgh, PA, 2006.
5. 20th Annual Roland D. Pinkham Basic Science Lectureship, Epigenetics: One Step above the Genome, ÒEnvironmental/Dietary Influences on Gene Imprinting and Consequences for Enhanced Disease Susceptibility,Ó Seattle, WA, 2006.
6. Distinguished Achievement Award, College of Engineering, University of Wisconsin, Madison, WI, 2006.
7. Robert T. Simpson Endowed Lecture in Molecular Medicine, Department of Biochemistry and Molecular Biology, ÒEpigenetics in Human Health and Disease,Ó Pennsylvania State University, University Park, PA, 2007.
8. Featured Scientist on NOVA and ScienceNow Epigenetics Television Programs and The DNA Files program - Rewriting Heredity: Environment and the Genome and The People's Pharmacy NPR program - Sex Hormone Disruption.
9. Time Magazine Person of the Year Nominee, 2007.
10. Esther B. O'Keeffe Charitable Foundation Award Recipient, 2007.
11. Epigenetic Medicine Award Recipient, 2008.
12. Renaissance Weekend, Invited Participant, 2008.
International Meetings Organized
1. FASEB Summer research conference on "Neoplastic Transformation of Liver Cells", Copper Mountain, CO, 1988 (Co-chairman).
2. FASEB Summer Research Conference on ÒHepatic Regeneration and Carcinogenesis: Molecular and Cellular Pathways, Copper Mountain, CO, 1990 (Co-chairman).
3. FASEB Summer Research Conference on ÒHepatic Regeneration and Carcinogenesis: Molecular and Cellular Pathways, Snowmass Village, CO, 1992 (Chairman).
4. Genomic Imprinting Symposium, Durham, NC, 1998 (Chairman).
URL: http://www.geneimprint.com/site/meetings/1998-durham
5. Environmental Epigenomics, Imprinting and Disease Susceptibility, Durham, NC, 2005 (Chairman).
Invited Speaker at National and International Meetings
1. Faculty member, Workshop on Liver Cell Culture (sponsored by the American Tissue Culture Association and held at Alton Jones Cell Science Center, Lake Placid, New York), 1981.
2. International meeting on "Cellular Repair of Radiation Damage: Mechanisms and Modifying Agents", Eleventh L. H. Gray Conference, Glasgow, Scotland, July, 1983.
3. Symposium on the "Effect of Heat, Radiation and Pharmacological Agents on Tumor Microcirculation", Chemical modification of tumor blood flow. 34th Annual Meeting of the Radiation Research Society, 1986.
4. NCI symposium on "Regulation of Growth and Differentiation in Normal, Regenerative and Neoplastic Hepatocytes", 1986.
5. FASEB Summer research conference on "Neoplastic Transformation of Liver Cells", Copper Mt, Colorado, 1988.
6. Experimental Radiation Oncology Conference, Oregon State University, Portland, OR, 1989.
7. Symposium on the "Modification of Tumor Blood Flow for Therapeutic Gain". 37th Annual Meeting of the Radiation Research Society, 1989.
8. International Symposium on the "Normal and Neoplastic Growth in Hepatology: Interface Between Basic and Clinical Science, University of Bari, Bari, Italy, 1989.
9. Society of Toxicology. Target Organ Toxicity: Advanced Hepatotoxicity, "Regulation of Hepatocyte Proliferation", Miami Beach, FL. 1990.
10. FASEB Summer Research Conference on ÒHepatic Regeneration and Carcinogenesis: Molecular and Cellular Pathways, Copper Mt, Colorado, 1990.
11. Pharmaceutical Manufacturers Association, Cell Proliferative Responses and their Implication in Drug Safety Assessment. "Regulation of Hepatocyte Proliferation", Tampa, FL, 1990.
12. Health & Environmental Sciences Institute 2nd workshop on Mouse Liver Tumors. "The Role of Growth Factors in Liver Tumor Promotion". Washington, D.C., 1990.
13. Symposium on "Cytokines and Growth Factors in Radiation Oncology", 9th ICRR, Toronto, Canada, 1991.
14. NIEHS symposium on the "Molecular Mechanisms of Carcinogenesis in Humans and Rodents", Research Triangle Park, NC, 1991.
15. Health & Environmental Sciences Institute 3rd workshop on Mouse Liver Tumors (Organizer and participant), Washington, D.C., 1991.
16. FASEB Summer Research Conference on ÒHepatic Regeneration and Carcinogenesis: Molecular and Cellular Pathways, Snowmass Village, Colorado, 1992 (Chairman).
17. US-Japan Joint Workshop on "Genetic Analysis of Hepatocarcinogenesis", Honolulu, Hawaii, 1992.
18. First United European Gastroenterology Week. "The role of TGF-§ and the IGF-II/M6P receptor in liver regeneration and tumor promotion". Athens, Greece, 1992.
19. Radiation Research Society Symposia on Growth Factors and Cytokines. "The Role of Growth Factors in the Repair of Normal Tissue Injury", Dallas, TX, 1993.
20. AASLD Single Topic Symposium on Liver Regeneration. "The Role of TGF-§ in Liver Regeneration and Tumor Promotion", Airlie, Virginia, 1993.
21. Gordon Conference: Mechanisms of Toxicity. "TGF-§: Role in Liver Tumor Promotion and Regeneration", Meriden, NH, 1993.
22. Schering Foundation Workshop on Non-Genotoxic Carcinogenesis. "Liver Tumor Promotion and Breast Cancer Chemoprevention: Common Mechanisms", Cambridge, England, 1993.
23. EPA Symposia on Carcinogenesis and Human Risk Assessment. "Liver Tumor Promotion and Breast Cancer Chemoprevention: Common Mechanisms", RTP, NC, 1993.
24. 7th International Conference on Carcinogenesis and Risk Assessment. Liver Tumor Promotion and Breast Cancer Chemoprevention: Common Mechanisms", Austin, TX, 1993.
25. FASEB Summer Research Conference on ÒHepatic Regeneration and Carcinogenesis: Molecular and Cellular PathwaysÓ, Copper Mt, Colorado, 1994 (Co-chairman).
26. American Society of Investigative Pathology, Program Committee, 1995-1996.
27. American Society for Therapeutic Radiology and Oncology, Symposium on Treatment of Intrahepatic Cancers, ÒTransforming Growth Factor Beta: A Predictor of Normal Tissue Toxicity, Miami, FL, 1995.
28. FASEB Summer Research Conference on ÒCellular and Molecular Mechanism for Liver Growth RegulationÓ, Snowmass Village, CO, 1996, (Co-chairman).
29. The British Toxicology Society Annual Meeting on ÒTumor suppressor gene imprinting and risk assessmentÓ, Brighton, UK, 1996.
30. Chinese Society for Therapeutic Radiology and Oncology, R.O.C. Annual Meeting on ÒM6P/IGF2 receptor: a newly identified liver tumor suppressor geneÓ and ÒTransforming growth factor-beta: predictor of radiation-induced normal tissue damageÓ, Taipei, Taiwan, 1997.
31. Cold Spring Harbor Laboratory Meeting on ÒThe Regulation of Liver Gene Expression in Health and DiseaseÓ, Cold Spring Harbor, NY, 1997.
32. 79th Annual Meeting of The Endocrine Society, Minneapolis, MN, 1997.
33. Society of Toxicology Workshop on ÒMouse Liver TumorsÓ, Chapel Hill, NC, 1997.
hh. Falk Workshop on ÒNormal and Malignant Liver Cell GrowthÓ, Halle, Germany, 1998.
34. University of Manchester, Division of Biological Sciences Seminar Series, ÒGenomic Imprinting and Disease SusceptibilityÓ, Manchester, UK, 1998.
35. Radiation Research Society Meeting course on ÒConcepts in Carcinogenesis: Role of Imprinted GenesÓ, Louisville, KY, 1998.
36. CASL Conference on Hepatocellular Carcinoma: Science and Practice, Niagara-on-the-Lake, Canada, 1998.
37. FASEB Summer Research Conference on ÒMechanisms of Liver Growth and Differentiation in Health and DiseaseÓ, Snowmass Village, CO, 1998.
38. 28th Annual European Environmental Mutagen Society Meeting, Salzburg, Austria, 1998.
39. Duke University/NIEHS Joint Symposium on ÒGenomic Imprinting and Disease SusceptibilityÓ, Durham, NC, 1998 (Chairman and Organizer).
40. NIEHS Annual Leadership Retreat, Pine Hurst, NC, 1999.
41. International Genomic Imprinting Symposium, ÒM6P/IGF2R: An Imprinted Tumor SuppressorÓ, Dublin, Ireland, 1999.
42. EUROTOX 2000 Meeting, ÒM6P/IGF2R Imprinting Evolution and CancerÓ, London, UK, 2000.
43. International Genomic Imprinting Symposium, ÒEvolution and Regulation of Imprinted GenesÓ, Osaka, Japan, 2001.
44. SNPs & Pharmacogenomics Conference; ÒUsing SNPs to Study the Evolution and Regulation of Imprinted GenesÓ, Philadelphia, PA, (Chairman), 2001.
45. FASEB Summer Research Conference on Growth Factor, Receptor Tyrosine Kinases in Mitogenesis, Morphogenesis and Tumorigenesis, ÒImprinting in Growth and Anti-GrowthÓ, Snowmass Village, CO, 2001.
46. AACR Symposium on Molecular Aspects of GI Cancers, ÒGenomic Imprinting Evolution and Cancer SusceptibilityÓ, Seoul, Korea, 2001.
47. Society for Women's Health Research symposium on Sex Begins in the Womb, ÒBiological Consequences of Imprinting EvolutionÓ, Palo Alto, CA, 2002.
48. NIEHS US-Japan Panel Environmental Mutagenesis and Carcinogenesis Meeting, Kauai, Hawaii, 2002.
49. Imprinting and Growth Congress 2002, ÒEvolution of Imprinted Growth Regulatory GenesÓ, London, UK, 2002.
50. NIH Epigenetic Mechanisms in Human Disease Meeting, ÒBiological Consequences of Imprinting EvolutionÓ, Washington, D.C., 2002.
51. FASEB Summer research Conference on Mechanisms of Liver Growth, Differentiation & Molecular Pathogenesis of Hepatic Diseases, "Evolution of Imprinted Liver Cancer Susceptibility Genes", Snowmass Village, CO, 2002.
52. American Society of Preventive Oncology Meeting, "Imprinted Genes: Epigenetic Cancer Susceptibility Loci Modified by Early Nutrition", Philadelphia, PA, 2003.
53. Environmental Mutagen Society Colon Cancer Meeting, "The Impact of the Environment on Colon Cancer," Loss of Imprinting and Cancer Susceptibility: The Good News and The Bad News,Ó Miami Beach, Fl, 2003.
54. Aspen Cancer Conference, "Evolution of Imprinted Cancer Susceptibility Genes", Aspen, CO, 2003.
55. German Genetics Society Epigenetics Conference, ÒTransposons and Imprinted Genes: Early Nutrition and Chronic Disease SusceptibilityÓ, Kassel, Germany, 2003.
56. XII Congress on Gestational Trophoblastic Disease, "Evolution of Imprinted Tumor Susceptibility Genes", Boston, MA, 2003.
57. NIEHS and Duke University Integrated Toxicology Program on Obesity: Developmental Origins and Environmental Influences, ÒImprinted Genes and Transposons: Genetic and Epigenetic Targets for Obesity,Ó Durham, NC, 2004.
58. 2004 European Society of Human Genetics on epigenetics, "Imprinted Genes and Transposons: Epigenomic Targets Linking Fetal Nutrition with Adult Disease Susceptibility," Munich, Germany, 2004.
59. Frontiers in Human Embryonic Stem Cell Course/Symposium, ÒEvolution of Imprinted Disease Susceptibility Genes,Ó Participant, Pittsburgh, PA, 2004.
60. Longevity Consortium Symposium, "Imprinted Genes and Transposons: Epigenomic Targets Linking Fetal Nutrition with Adult Disease Susceptibility," New York, NY, 2004.
61. 3rd Annual Meeting of the International Society of Pharmacogenomics ÒFrom Human Genetic Variations to Prediction of Risks and Responses to the Environment,Ó "Imprinted Genes and Transposons: Epigenomic Targets Linking Fetal Nutrition with Adult Disease Susceptibility," Santorini Island, Greece, 2004.
62. Genetic and Environmental Mutagenesis Society Meeting, "Imprinted Genes and Transposons: Epigenomic Targets Linking Prenatal Nutrition to Adult Chronic Diseases," Chapel Hill, NC, 2004.
63. Sixth Annual Conference on Sex and Gene Expression (SAGE VI), "Imprinted Genes and Transposons: Epigenomic Targets Linking Fetal Nutrition with Adult Disease Susceptibility," Winston-Salem, NC, 2005.
64. Bovine Genome Project: The Next Phase International Workshop. Panel member of session entitled "The Interface with the Biomedical Community: What are the Opportunities?", Houston, TX, 2005.
65. NIEHS Environmental Genomics Workshop in Research Triangle Park, NC, 2005.
66. Member, AACR Human Epigenome Task Force, Philadelphia, PA, 2006-2007.
67. NIH Epigenetics Roadmap Initiative Workshop, Washington, DC, 2007.
68. Collins Distinguished Lecture Series, ÒEpigenetics, Imprinting, and Disease SusceptibilityÓ, Department of Radiation Oncology, Harvard University, Boston, MA, 2008.
69. Harvard School of Public Health Distinguished Lecture Series, ÒEpigenetics: The New Genetics of Toxicology,Ó Harvard University, Boston, MA, 2008.
Invited Seminars
1977
1. Stanford University, Department of Radiology, Stanford, CA
2. University of New Mexico, Cancer Research and Treatment Center, Albuquerque, NM
3. Mayo Clinic, Department of Therapeutic Radiology, Rochester, MN
4. Duke University, Department of Radiology, Durham, NC
1979
1. The University of Wisconsin-Madison, Department of Zoology, Madison, WI
2. The Johns Hopkins Oncology Center, Division of Radiobiology, Baltimore, MD
1981
1. The University of Wisconsin-Madison, Department of Human Oncology, Madison, WI
1982
1. McGill University, Department of Pharmacology and Therapeutics, Montreal, Canada
2. ENEA-C.R.E., Casaccia, Roma, Italia, Department of Pathology, Rome, Italy
1983
1. The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Department of Therapeutic Radiology, Houston, TX
2. Northwestern University, Department of Pathology, Chicago, IL
3. Duke University, Cancer Center Seminar Series, Durham, NC
4. University of North Carolina, Department of Pathology, Chapel Hill, NC
1984
1. Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico
2. ENEA-C.R.E., Casaccia, Roma, Italia, Department of Pathology, Rome, Italy
3. Duke University, Gastroenterology Seminar Series, Durham, NC
1986
1. National Institute of Health Conference on Regulation of Growth and Differentiation in Normal, Regenerative and Neoplastic Hepatocytes, Bethesda, MD
1987
1. British Columbia Cancer Research Centre, Vancouver, B.C., Canada
2. University of Washington, Radiation Oncology Dept., Seattle, WA
3. University of Wisconsin Department of Human Oncology, Madison, WI
4. Wake Forest University, Winston-Salem, NC
5. Yale University, New Haven, CT
6. US EPA, Chicago, IL
1988
1. Duke University, Department of Medicine, Division of Gastroenterology, Durham, NC
2. FASEB Summer Research Conference on Neoplastic Transformation of Liver Cells, Copper Mountain, CO
1989
1. University of North Carolina, Department of Pathology, Chapel Hill, NC
2. Oregon State University, Portland, OR
3. Fred Hutchinson Cancer Center, Seattle, WA
4. Normal and Neoplastic Growth in Hepatology: Interface between Basic and Clinical Science, Bari, Italy
5. Institute of Pathology, Munich, Germany
6. University of Salzburg, Department of Genetics, Salzburg, Austria
7. Institut fur Tumorbiologie-Krebsforschung, Vienna, Austria
8. University of Toronto, Toronto, Canada
9. National Symposium on Water Quality Assessment, Ft. Collins, CO
1990
1. University of Wisconsin-Madison, Madison, WI
2. Continuing Education Course in: Target Toxicity: Advance Hepatotoxicity, SOT, Miami Beach, FL
3. FASEB Summer Research Conference on Hepatic Regeneration and Carcinogenesis, Copper Mountain, CO
4. PMA Meeting on Cell Proliferative Responses and their Implications in Drug Safety Assessment, Tampa, FL
5. 2nd ILSI Workshop on Mouse Liver Tumors, Washington, DC
1991
1. Procter and Gambles, Inc., Cincinnati, OH
2. 9th ICRR meeting, Toronto, Canada
3. University of Pittsburgh, Pittsburgh, PA
4. NIEHS, Seminars in Receptor Mechanisms, Research Triangle Park, NC
5. NIEHS, Symposium on "Molecular Mechanisms of Carcinogenesis in Humans and Rodents, Research Triangle Park, NC
6. 3rd ILSI Workshop on Mouse Liver Tumors, Washington, DC
7. University of North Carolina, Chapel Hill, NC
1992
1. US-Japan Joint Workshop on Liver Carcinogenesis, Honolulu, Hawaii
2. Hoffmann-LaRoche, Nutley, NJ
3. FASEB Summer Research Conference on ÒHepatic Regeneration and Carcinogenesis, Snowmass Village, CO
4. International Gastroenterology Meeting, Athens, Greece
5. Genetics Institute, Cambridge, MA
6. Late Effects Workshop, San Francisco, CA
7. ILSI Meeting on Mouse Liver Tumors, Washington, DC
1993
1. Michigan State University, E. Lansing, MI
2. University of North Carolina, Chapel Hill, NC
3. Zeneca Pharmaceuticals, Ltd, Macclesfield, UK
4. Cambridge University, Cambridge, UK
5. MD Anderson, Austin, TX
1994
1. Albert Einstein College of Medicine, Bronx, NY
2. NC Society of Radiologic Technologists, Research Triangle Park, NC
3. 4th ILSI Workshop on Mouse Liver Tumors, Washington, DC
4. Hoffmann-La Roche, Nutley, NJ
5. FASEB Summer Research Conference, Copper Mt, CO
6. Nexagen, Boulder, CO
7. Medical College of Virginia, Richmond, VA
1995
1. Genzyme, Boston, MA
2. Zeneca Pharmaceuticals, Ltd, Macclesfield, UK
3. University of Leicester (MRC Toxicology), Leicester, England
4. Rutger University (New Jersey Cancer Institute), New Brunswick, NJ
5. University of Pittsburgh, Pittsburgh, PA
6. Procter & Gamble, Cincinnati, OH
1996
1. Procter & Gamble, Cincinnati, OH
2. 21st Meeting of the International Association for Breast Cancer Research, Paris, France
3. FASEB Summer Research Conference on Cellular and Molecular Mechanisms for Liver Growth Regulation, Snowmass, CO
4. Autumn Meeting of The British Toxicology Society, Brighton, UK
5. Zeneca Pharmaceuticals, Ltd, Macclesfield, UK
6. Rohm & Haas, Spring House, PA
1997
1. Chinese Society for Therapeutic Radiology and Oncology, Taipei, Taiwan
2. Sun Yet-Sen Cancer Center, Taipei, Taiwan
3. National Taiwan University Medical Center, Taipei, Taiwan
4. The Cancer Institute, Tokyo, Japan
5. Sumitomo Chemical, Osaka, Japan
6. Albert Einstein College of Medicine, Bronx NY
7. Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA
8. Cold Spring Harbor Laboratory Meeting on Regulation of Liver Gene Expression in Health and Disease, Cold Spring Harbor, NY
9. Brown University, Providence, RI
10. The Endocrine Society, Minneapolis, MN
11. SOT Mouse Liver Tumor Workshop, Chapel Hill, NC
12. Zeneca Pharmaceuticals, Ltd, Macclesfield, UK
1998
1. Falk Workshop on Normal and Malignant Liver Cell Growth, Halle, Germany.
2. University of Pittsburgh, Pittsburgh, PA
3. Zeneca Pharmaceuticals, Ltd, Macclesfield, UK
4. University of Manchester, Manchester, UK.
5. CASL Conference on Hepatocellular Carcinoma: Science and Practice, Niagara-on-the-Lake, Canada.
6. FASEB Summer Research Conference on Liver Growth and Differentiation in Health and Disease, Snowmass, CO.
7. European Environmental Mutagen Society Meeting, Salzburg, Austria
8. Zeneca Pharmaceuticals, Ltd, Wilmington, DL
9. Rohm & Haas, Spring House, PA
10. University of North Carolina-Chapel Hill, Chapel Hill, NC
1999
1. NIEHS, Annual Leadership Retreat, Pine Hurst, NC
2. Tufts University, Boston, MA
3. Sigma Xi Lecture, Research Triangle Park, NC
4. Genomic Imprinting Symposium, Dublin, Ireland
2000
1. Dupont Pharmaceuticals, Inc. Philadelphia, PA
2. Parke-Davis Pharmaceuticals, Inc. Ann Arbor, MI
3. East Carolina University, Greenville, NC
4. EUROTOX 2000 Meeting, London, UK
5. NCI Modifying Normal Tissue Damage Post-irradiation Workshop, Washington, D.C.
6. Medical College of Wisconsin, Milwaukee, WI
7. LabCorp, Inc. Research Triangle Park, NC
2001
1. National Institutes of Health AAV Safety Symposium, Washington, D.C.
2. University of Wisconsin-Madison, Madison, WI
3. NIEHS, NIH, Research Triangle Park, NC
4. U.S. Meat Animal Research Center, Clay Center, NE
5. University College Dublin, UCD, Dublin, Ireland
6. FASEB Summer Research Conference, Snowmass Village, CO
7. AACR Symposium, Molecular Aspects of GI Cancers, Seoul, Korea
2002
1. Society for Women's Health Research Symposium, Palo Alto, CA, 2002.
2. NIEHS US-Japan Panel Environmental Mutagenesis and Carcinogenesis Meeting, Kauai, Hawaii, 2002.
3. Imprinting and Growth Congress 2002, London, UK, 2002.
4. NIH Epigenetic Mechanisms in Human Disease Meeting, Washington, D.C., 2002.
5. FASEB Summer research Conference on Mechanisms of Liver Growth, Differentiation & Molecular Pathogenesis of Hepatic Diseases, Snowmass Village, CO, 2002.
6. Szulman Lecture, University of Pittsburgh, Pittsburgh, PA
7. CIIT Centers for Health Research, Research Triangle Park, NC
2003
1. Duke Comprehensive Cancer Center's Therapeutics Development Group, Durham, NC
2. American Society of Preventive Oncology Meeting, Philadelphia, PA
3. Medicine Grand Rounds, Duke University Medical Center, Durham, NC
4. Toxicology Seminar, Duke University, Durham, NC
5. Distinguished Seminar Series, NCI-Fredrick, Fredrick, MD
6. Environmental Mutagen Society, Miami, FL
7. Aspen Cancer Conference, Aspen, CO
8. German Genetics Society Meeting, KŠssel, Germany
9. XIIth World Congress on Gestational Trophoblastic Disease, Boston, MA
10. University of Vermont, Burlington, VT
2004
1. Biology, Anthropology and Anatomy Department Seminar, Duke University, Durham, NC
2. Biomedical Engineering Seminar, Duke University, Durham, NC
3. Cancer Control Seminar, Duke University Medical Center, Durham, NC
4. Molecular Carcinogenesis Divisions Seminar, NIEHS, Research Triangle Park, NC
5. Toxicology Meeting on Obesity: Developmental Origins and Environmental Influences, Duke University/NIEHS, Durham, NC
6. NIEHS/ACC Meeting on Developmental Toxicology and Fetal Basis of Adult Disease, Research Triangle Park, NC
7. European Society of Human Genetics Meeting, Munich, Germany
8. Frontiers in Human Embryonic Stem Symposium, Pittsburgh, PA
9. Nobel Symposium on Epigenetic Reprogramming in Development and Disease, Stockholm, Sweden
10. Pediatric Academic Societies' Annual Meeting on Epigenetics and its Role in Programming Symposium, San Francisco, CA
11. Neonatal-Perinatal Research Institute, Duke University Medical Center, Durham, NC
12. International Society of Pharmacogenomics Santorini Conference on From Human Genetic Variations to Prediction of Risks and Responses to the Environment, Santorini Island, Greece
13. Liver Genetics and Development Symposium, UCSF Liver Center, San Francisco, CA
14. American Diabetes Association's 64th Scientific Meeting on DNA Methylation and Regulation of Body Fat, Orlando, FL
15. Longevity Consortium Symposium, New York, NY
16. NIH Seminar, Department of Pathology, Bethesda, MD.
17. Toxicology Seminar, North Carolina State University, Environmental and Molecular Toxicology Department, Raleigh, NC.
18. Department of Pathology Seminar, Duke University Medical Center, Durham, NC.
19. GEMS Meeting on DNA Methylation and its Toxicological Consequences, Chapel Hill, NC.
20. USDA Human Nutrition Research Center, Tufts University, Boston, MA.
21. Therapeutics Development Working Group Meeting, Duke University, Durham, NC.
2005
1. Sixth Annual Conference on Sex and Gene Expression (SAGE VI), Winston-Salem, NC.
2. Joint Breast Ovarian Cancer Meeting, Duke University, Durham, NC.
3. Life Sciences Research Office (LSRO) Nutrigenomics Think Tank, Bethesda, MD.
4. Bovine Genome Project: The Next Phase International Workshop, Houston, TX.
5. Therapeutics Development Working Group Meeting, Duke University, Durham, NC.
6. Brookdale Department of Molecular, Cell & Developmental Biology, Mount Sinai School of Medicine, New York, NY.
7. Low Dose Workshop, Department of Energy, Washington, DC.
8. 7th annual Symposium on the Environment and Hormones, Center for Bioenvironmental Research at Tulane and Xavier Universities, New Orleans. LA.
9. 36th Annual Meeting of the Environmental Mutagen Society, San Francisco, CA.
10. Department of Endocrinology, Grand Rounds, Duke University, Durham, NC.
11. Department of Nutrition, Nutritional Biochemistry Seminar, University of North Carolina-Chapel Hill , Chapel Hill, NC.
12. Duke/NIEHS Environmental Epigenomics Conference, Durham, NC.
2006
1. Joslin Diabetes Center Seminar, Boston, MA.
2. National Academy of Sciences-Toxicogenomics Meeting, Washington, DC.
3. Epigenetics Symposium, Society of Toxicology, San Diego, CA.
4. Epidemiology Scientific Symposium, Children's Oncology Group Meeting, Chicago, IL.
5. Molecular Biology Interdisciplinary Graduate Program, University of Iowa, Iowa City, IA.
6. Institute of Cancer Genetics Seminar Series, Columbia-Presbyterian Medical Center, New York, NY.
7. Epigenetics in Biology and Disease Symposium, Fred Hutchinson Cancer Research Center, Seattle, WA.
8. Fetterman Endowed Lecturer, University of Pittsburgh, Pittsburgh, PA.
9. NIH Neuroscience and Neuropsychology of Aging Workshop, Washington, DC.
10. Salzburg Biosemiotics Meeting, Salzburg, Austria.
11. Conference on Nutrition and Cancer, American Institute for Cancer Research, Washington, DC.
12. Department of Radiation Oncology, Medical College of Virginia, Richmond, VA.
13. Gene-environment Interactions and the Developmental Origins of Health and Disease, UC Irvine, Irvine, CA.
14. Department of Food Science and Human Nutrition Seminar, University of Illinois at Urbana-Champaign, Champaign, IL.
15. University of Minnesota Cancer Center, Minneapolis, MN.
16. Epigenetics in Obesity Symposium, NAASO, The Obesity Society Meeting, Boston, MA.
17. Epigenomics and Imprinting Session, AACR Conference on Frontiers in Cancer Prevention Research, Boston, MA.
18. Pinkham Conference on Basic Science Lectureship, Seattle, WA.
2007
1. ILSI-HESI Annual Meeting on Emerging Issues: Understanding the Importance of Transgenerational Inheritance of Epigenetic Changes, Cancun, Mexico.
2. Keystone Symposia on Reproduction: Advances and Challenges, Santa Fe, NM.
3. LSRO Nutrigenomics Meeting on Emerging Issues in Science: Inflammation and Obesity, Bethesda, MD.
4. Duke University, Nicholas School of the Environment, Durham, NC.
5. Robert T. Simpson Endowed Lecture in Molecular Medicine, ÒEpigenetics in Human Health and Disease,Ó Pennsylvania State University, University Park, PA.
6. NIH Epigenetics Roadmap Workshop, Bethesda, MD.
7. University of ZŸrich Toxicology Seminar, ZŸrich, Switzerland.
8. University of Lausanne Toxicology Seminar, Lausanne, Switzerland.
9. Linus Pauling Institute and the Oxygen Club of California, Diet and Optimum Health Conference, Portland, OR.
10. University of Vienna and Austrian Scientists for Nature Protection, Epigenetics Symposium, Vienna, Austria.
11. University of Salzburg Seminar, Salzburg, Austria.
12. 4th International Conference on the Female Reproductive Tract, Kloster Frauenwšrth, Frauenchiemsee, Germany.
13. 13th International Congress of Radiation Research, Topical Reviews Program, San Francisco, CA.
14. The Jackson Laboratory Seminar, Bar Harbor, ME.
15. Toxicogenomics Integrated with Environmental Sciences Conference, NC State University, Raleigh, NC.
15. OLLI at Duke Seminar, Forest at Duke Retirement Community, Durham, NC
16. 38th Annual Environmental Mutagenesis Society meeting, Topical Review, Atlanta, GA.
17. 20th Anniversary Superfund Basic Research Program Meeting, Durham, NC.
18. DOE BERÕs Advisory Committee Review, Washington, DC.
2008
1. CEHS Seminar Series presentation at the University of North Carolina, Chapel Hill, NC.
2. Epigenetics & Law Seminar, Panel Participant at Duke University, Durham, NC.
3. Fetal Physiology Foundation Symposium, Johns Hopkins University, Baltimore, MD.
4. Multidisciplinary Workshop on Nutrition, Brain Development and Aging: Genetics, Epigenetics and Behavior, UNC-Chapel Hill, Kannapolis, NC.
5. National Scientific Council on the Developing Child at Harvard Meeting, Washington, DC.
6. Mount Desert Island Stem Cell Symposium, Salisbury Cove, ME.
7. Collins Lecture, Massachusetts General Hospital, Harvard University, Boston, MA.
8. Massachusetts General Hospital Center for Cancer Research seminar, Harvard University, Boston, MA.
9. Department of Environmental and Occupational Health Seminar, University of Pittsburgh, Pittsburgh, PA.
10. Center for Environmental Oncology Seminar, University of Pittsburgh Cancer Institute, Pittsburgh, PA.
11. Center for Drug Evaluation and Research (CDER) Seminar, U.S. Food and Drug Administration (FDA), Washington, DC.
12. MD Anderson Cancer Center Seminar, Houston, TX.
13. NC State Toxicology Seminar, North Carolina State University, Raleigh, NC.
14. Endocrinology, Health and the Environment seminar series, Rutgers University, New Brunswick, NJ.
15. UNC-Chapel Hill Department of Cell and Molecular Physiology Seminar, Chapel Hill, NC.
16. EPA Science Advisory Board meeting, Washington, DC.
17. GI Grand Rounds, Duke University, Durham, NC.
18. Harvard School of Public Health Distinguished Lecture Series, Boston, MA.
19. National Cancer Institute, FCRDC seminar, Fredrick, MD.
20. NCI Invited Speaker Series, Washington, DC.
21. NIH Workshop, Dynamic Epigenome and Homeostatic Regulations in Health and Disease, Bethesda, MD.
Editorial Board Member
Hepatology (1998 - 2002)
Toxicology Sciences (1998 - present)
Comparative Hepatology - BioMed Central (2002 - present)
TheScientificWorldJOURNAL - Embryology Domain (2002 - present)
Epigenetics (2005 - present)